Methyl 4-(bromomethyl)benzoate → HCID 66621956, compound

HRID 416261Notes

Reaction equation

HRID 416261 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][N:12]=[C:11]([SH:15])[N:10]=2)=[CH:5][CH:4]=1.[CH3:16][O:17][C:18](=[O:27])[C:19]1[CH:24]=[CH:23][C:22]([CH2:25]Br)=[CH:21][CH:20]=1>CN(C=O)C>[CH3:16][O:17][C:18](=[O:27])[C:19]1[CH:24]=[CH:23][C:22]([CH2:25][S:15][C:11]2[N:10]=[C:9]([C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[CH:14]=[CH:13][N:12]=2)=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 256687Methyl 4-(bromomethyl)benzoateHCID 178488671HCID 178488671, compound

Product 1

HCID 66621956HCID 66621956, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 4-(4-methoxy-phenyl)-pyrimidine-2-thiol (225a) (1.00 g, 4.58 mmol) in DMF (30 mL) was added 4-bromomethyl-benzoic acid methyl ester (1.05 g, 4.58 mmol). The mixture was heated at 60° C. for 1 h and evaporated to dryness to form the compound 226a, which was used in the next without purification. LRMS=366.4 (calc.), 367.4 (found).

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-609334d1dae24bea932f1e8216524245
Source dataset
uspto-grants-2012_01
Patent number
US08088805B2

Reaction notes

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