Acetylpyrazine → N-(2-Aminophenyl)-4-((4-(2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide

HRID 416279Notes

Reaction equation

HRID 416279 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:30])[C:10]1[CH:15]=[CH:14][C:13]([CH2:16][NH:17][C:18]2[N:23]=C(C3C=NC=CN=3)C=[CH:20][N:19]=2)=[CH:12][CH:11]=1.N1C=CN=CC=1C(=O)C.[CH3:40][C:41]1[N:42]=[C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][N:44]2[C:49]=1[C:50](=O)[CH3:51]>>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:30])[C:10]1[CH:15]=[CH:14][C:13]([CH2:16][NH:17][C:18]2[N:23]=[C:50]([C:49]3[N:44]4[CH:45]=[CH:46][CH:47]=[CH:48][C:43]4=[N:42][C:41]=3[CH3:40])[CH:51]=[CH:20][N:19]=2)=[CH:12][CH:11]=1

Participants

4

Reactant 3

HCID 30914AcetylpyrazineHCID 27352551-{2-Methylimidazo[1,2-a]pyridin-3-yl}ethan-1-oneHCID 44570891N-(2-aminophenyl)-4-((4-(pyrazin-2-yl)pyrimidin-2-ylamino)methyl)benzamide

Product 1

HCID 58930542N-(2-Aminophenyl)-4-((4-(2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide

Procedure

Title compound was obtained according to the scheme 6 similarly to the compound 26a (Example 29) using instead of 1-pyrazin-2-yl-ethanone as the starting material the ketone 333 (Table 11). Characterization of the title compound is provided in the Table 12.

Sources & evidence

ORD record
ord-67076c2045014952bd28ffe83898422e
Source dataset
uspto-grants-2012_01
Patent number
US08088805B2

Reaction notes

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