反应详情

温度

2.5 °C

To a solution of (S)-2-(tert-butoxycarbonylamino)-3-(1H-imidazol-4-yl)propanoic acid (1.0 g, 3.92 mmol) in THF (20 mL) was added LAH (2 M, 10 mL, 20 mmol) at 0-5° C. The reaction mixture was stirred at 0-5° C. for 30 min and heat to reflux for 2 h. The reaction mixture was cooled to 0-5° C. and quenched with water (0.8 mL), NaOH (0.8 mL), and water (2.4 mL). The resulting suspension was stirred RT for 30 min and filtered. The filtrate was concentrated to give (S)-3-(1H-imidazol-4-yl)-2-(methylamino)propan-1-ol (400 mg, crude), which was used without further purification. LRMS (M-Boc+H+) m/z 156.1.

1. temperatureheat
2. temperatureto reflux for 2 h
3. temperatureThe reaction mixture was cooled to 0-5° C.
4. customquenched with water (0.8 mL), NaOH (0.8 mL), and water (2.4 mL)
5. stirringThe resulting suspension was stirred RT for 30 min
6. filtrationfiltered
7. concentrationThe filtrate was concentrated