HRID416478

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11474

Piconol

C6H7NO

HCID75644

Cyclopropylmethanol

C4H8O

结构：O=C(N[C@@H]1CCCC[C@H]1O)c1nc(-c2ccc(Cl)cc2)c(OCC2CC2)nc1C(F)(F)F

HCID44466570

未命名化合物

结构：O=C(N[C@@H]1CCCC[C@H]1O)c1nc(-c2cccc(Cl)c2)c(Br)nc1C(F)(F)F

HCID86634705

未命名化合物

PRODUCTS

生成物

结构：O=C(N[C@@H]1CCCC[C@H]1O)c1nc(-c2cccc(Cl)c2)c(OCc2ccccn2)nc1C(F)(F)F

HCID44463460

未命名化合物

PROCEDURE

实验过程

In analogy to example 1 (6-(4-chloro-phenyl)-5-cyclopropylmethoxy-3-trifluoromethyl-pyrazine-2-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide) this compound was prepared by substituting 5-bromo-6-(4-chloro-phenyl)-3-trifluoromethyl-pyrazine-2-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide with 5-bromo-6-(3-chloro-phenyl)-3-trifluoromethyl-pyrazine-2-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide and cyclopropylmethanol with pyridin-2-yl-methanol.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bbbde96156914d04a01467967dd8983d
来源数据集: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08088920B2
来源说明: uspto-grants-2012_01

反应 SMILES

O[C@@H]1CCCC[C@H]1NC(C1C(C(F)(F)F)=N[C:14]([O:21]CC2CC2)=[C:13]([C:26]2[CH:31]=[CH:30][C:29](Cl)=CC=2)[N:12]=1)=O.[OH:33][C@@H:34]1[CH2:39][CH2:38][CH2:37][CH2:36][C@H:35]1[NH:40][C:41]([C:43]1[C:48]([C:49]([F:52])([F:51])[F:50])=[N:47][C:46](Br)=[C:45]([C:54]2[CH:59]=[CH:58][CH:57]=[C:56]([Cl:60])[CH:55]=2)[N:44]=1)=[O:42].C1(CO)CC1.N1C=CC=CC=1CO>>[OH:33][C@@H:34]1[CH2:39][CH2:38][CH2:37][CH2:36][C@H:35]1[NH:40][C:41]([C:43]1[C:48]([C:49]([F:52])([F:51])[F:50])=[N:47][C:46]([O:21][CH2:14][C:13]2[CH:26]=[CH:31][CH:30]=[CH:29][N:12]=2)=[C:45]([C:54]2[CH:59]=[CH:58][CH:57]=[C:56]([Cl:60])[CH:55]=2)[N:44]=1)=[O:42]