2-Phthalimidoethanesulfonyl chloride → 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (1-cyclopropyl-piperidin-4-yl)-amide

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Reaction Steps

2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (1-cyclopropyl-piperidin-4-yl)-amide was prepared by an analogous procedure as described for example 1 i) starting from 154 mg (1.1 mmol) 1-cyclopropyl-piperidin-4-ylamine (obtainable as described in EP 1479676) and 300 mg (1 equiv.) 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonyl chloride. The product was obtained in crude form as a colorless foam.

Provenance & Evidence