HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Phthalimidoethanesulfonyl chloride → 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (1-isopropyl-piperidin-4-yl)-methyl-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Phthalimidoethanesulfonyl chloride | HCID 308739 | — |
| Reactant | N-methyl-1-(propan-2-yl)piperidin-4-amine | HCID 3159676 | — |
| Product | 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (1-isopropyl-piperidin-4-yl)-methyl-amide | HCID 66624342 | — |
Reaction Steps
2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (1-isopropyl-piperidin-4-yl)-methyl-amide was prepared by an analogous procedure as described for example 1 i) starting from 171.3 mg (1.1 mmol) (1-isopropyl-piperidin-4-yl)-methyl-amine and 300 mg (1 equiv.) 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonyl chloride. 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (1-isopropyl-piperidin-4-yl)-methyl-amide was obtained as a light yellow foam. Yield: 385 mg MS (ES+): m/e=394.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088925B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-aab168e1378e43c2a419f874ff73e027 |
| Source note | uspto-grants-2012_01 |