Methylamine → HCID 66625054, compound

Participants

Reaction Steps

156.0 mg (0.27 mmol) 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (1-isopropyl-piperidin-4-yl)-(2,2,2-trifluoro-ethyl)-amide were dissolved in 5 ml MeOH. 2.98 ml (22 equiv.) of a 2 M methylamine-solution in MeOH were added and the reaction mixture was stirred at room temperature for 20 h. The mixture was concentrated under reduced pressure to give crude 2-amino-ethanesulfonic acid (1-isopropyl-piperidin-4-yl)-(2,2,2-trifluoro-ethyl)-amide.

Provenance & Evidence