Methylamine → HCID 66625054, compound

HRID 416497Notes

Reaction equation

HRID 416497 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10]([CH2:27][C:28]([F:31])([F:30])[F:29])[S:11]([CH2:14][CH2:15][N:16]2C(=O)C3C(=CC=CC=3)C2=O)(=[O:13])=[O:12])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].CN>CO>[CH:1]([N:4]1[CH2:5][CH2:6][CH:7]([N:10]([CH2:27][C:28]([F:31])([F:30])[F:29])[S:11]([CH2:14][CH2:15][NH2:16])(=[O:12])=[O:13])[CH2:8][CH2:9]1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 66624821HCID 66624821, compound

Product 1

HCID 66625054HCID 66625054, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

156.0 mg (0.27 mmol) 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (1-isopropyl-piperidin-4-yl)-(2,2,2-trifluoro-ethyl)-amide were dissolved in 5 ml MeOH. 2.98 ml (22 equiv.) of a 2 M methylamine-solution in MeOH were added and the reaction mixture was stirred at room temperature for 20 h. The mixture was concentrated under reduced pressure to give crude 2-amino-ethanesulfonic acid (1-isopropyl-piperidin-4-yl)-(2,2,2-trifluoro-ethyl)-amide.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-b4b4835c2d774042b5cfe79dc07a87da
Source dataset
uspto-grants-2012_01
Patent number
US08088925B2

Reaction notes

Loading…