HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3-Chloropropoxy)oxane → Formate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3-Chloropropoxy)oxane | HCID 254954 | — |
| Reactant | 5-Chloro-Thiophene-2-Carboxylic Acid [2-(1--Isopropyl-Piperidin-4-Ylsulfamoyl)-Ethyl]-Amide | HCID 11990478 | — |
| Product | Formate | HCID 283 | — |
| Product | 5-Chloro-thiophene-2-carboxylic acid (2-{(1-isopropyl-piperidin-4-yl)-[3-(tetrahydro-pyran-2-yloxy)-propyl]-sulfamoyl}-ethyl)-amide | HCID 66624965 | — |
Reaction Steps
5-Chloro-thiophene-2-carboxylic acid (2-{(1-isopropyl-piperidin-4-yl)-[3-(tetrahydro-pyran-2-yloxy)-propyl]-sulfamoyl}-ethyl)-amide was prepared by an analogous procedure as described in example 15 starting from 245 mg (1.5 equiv.) 2-(3-chloro-propoxy)-tetrahydro-pyran and 360 mg (0.91 mmol) 5-chloro-thiophene-2-carboxylic acid [2-(1-isopropyl-piperidin-4-ylsulfamoyl)-ethyl]-amide. Final purification by preparative RP-HPLC (CH3CN/H2O gradient+0.05% formic acid) gave pure 5-chloro-thiophene-2-carboxylic acid (2-{(1-isopropyl-piperidin-4-yl)-[3-(tetrahydro-pyran-2-yloxy)-propyl]-sulfamoyl}-ethyl)-amide as its formate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088925B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-1b71ff41d8d248618cbc5a65721d9f28 |
| Source note | uspto-grants-2012_01 |