1-(Propan-2-yl)piperidin-4-amine → HCID 66624637, compound

HRID 416525Notes

Reaction equation

HRID 416525 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([NH2:10])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[CH2:11]([O:18][C:19](=[O:36])[NH:20][C@@H:21]([CH2:27][O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:22][S:23](Cl)(=[O:25])=[O:24])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:11]([O:18][C:19](=[O:36])[NH:20][C@@H:21]([CH2:27][O:28][CH2:29][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)[CH2:22][S:23](=[O:25])(=[O:24])[NH:10][CH:7]1[CH2:8][CH2:9][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6]1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 31633331-(Propan-2-yl)piperidin-4-amineHCID 86621460HCID 86621460, compound

Product 1

HCID 66624637HCID 66624637, compound

Procedure

[(S)-1-Benzyloxymethyl-2-(1-isopropyl-piperidin-4-ylsulfamoyl)-ethyl]-carbamic acid benzyl ester was prepared by an analogous procedure as described for example 26 vi) starting from 142 mg (1.0 equiv.) 1-isopropyl-piperidin-4-ylamine and 398 mg (1.0 mmol) ((S)-1-benzyloxymethyl-2-chlorosulfonyl-ethyl)-carbamic acid benzyl ester. The product was obtained in crude form as a light yellow foam. Yield: 217 mg MS (ES+): m/e=504.

Workup

  1. customThe product was obtained in crude form as a light yellow foam

Sources & evidence

ORD record
ord-2e8f9cff81d94731a22cf48f820ee5e7
Source dataset
uspto-grants-2012_01
Patent number
US08088925B2

Reaction notes

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