Morpholine → HCID 66624635, compound

HRID 416531Notes

Reaction equation

HRID 416531 reaction equation
C1C2C(COC(=O)[NH:17][C:18]([CH3:34])([CH3:33])[CH2:19][S:20](=[O:32])(=[O:31])[NH:21][CH:22]3[CH2:27][CH2:26][N:25]([CH:28]([CH3:30])[CH3:29])[CH2:24][CH2:23]3)C3C(=CC=CC=3)C=2C=CC=1.N1CCOCC1>CN(C=O)C>[CH:28]([N:25]1[CH2:26][CH2:27][CH:22]([NH:21][S:20]([CH2:19][C:18]([NH2:17])([CH3:33])[CH3:34])(=[O:32])=[O:31])[CH2:23][CH2:24]1)([CH3:30])[CH3:29]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 66625201HCID 66625201, compound

Product 1

HCID 66624635HCID 66624635, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

607 mg (1.2 mmol) of crude [2-(1-isopropyl-piperidin-4-ylsulfamoyl)-1,1-dimethyl-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester were dissolved in 6 ml DMF. 1.5 ml morpholine were added and the resulting mixture was stirred for 2 h at room temperature. The reaction mixture was filtered. The filtrate was concentrated under reduced pressure and co-distilled three times with 20 ml DMF to give crude 2-amino-2-methyl-propane-1-sulfonicacid (1-isopropyl-piperidin-4-yl)-amide as yellow oil. Yield: 360 mg MS (ES+): m/e=278.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c0f3363d2e6c49bcb9edbbb5b5391722
Source dataset
uspto-grants-2012_01
Patent number
US08088925B2

Reaction notes

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