Thionyl Chloride → HCID 22266503, compound

HRID 416589Notes

Reaction equation

HRID 416589 reaction equation
O1C2C=CC=CC=2N=C1O[CH2:11][C:12]1[C:13](=[O:22])[N:14]([CH2:18][CH2:19][CH2:20][CH3:21])[CH:15]=[CH:16][CH:17]=1.S(Cl)([Cl:25])=O>C(Cl)Cl>[CH2:18]([N:14]1[CH:15]=[CH:16][CH:17]=[C:12]([CH2:11][Cl:25])[C:13]1=[O:22])[CH2:19][CH2:20][CH3:21]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 22266527HCID 22266527, compound

Product 1

HCID 22266503HCID 22266503, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-(benzoxazol-2-yloxymethyl)-1-butyl-2-pyridone (7-008-03) (169 mg) in methylene chloride (4.0 mL) was added thionyl chloride (122 mg) at room temperature. After stirring for 1 h, the solvent was removed to 1-butyl-3-chloromethyl-2-pyridone (7-008-04) as an oil.

Workup

  1. customthe solvent was removed to 1-butyl-3-chloromethyl-2-pyridone (7-008-04) as an oil

Sources & evidence

ORD record
ord-21c7abf0912e4c67b5a3160ebd64be6e
Source dataset
uspto-grants-2012_01
Patent number
US08088924B2

Reaction notes

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