反应详情

温度

60 °C

To a suspension of 4-chloroselenobenzamide (219 mg, 1 mmol) and 2-chloromalonaldehyde (160 mg, 1.5 mmol) in 1,2-dimethoxyethane (1.5 ml) is added magnesium carbonate (42 mg, 0.5 mmol) and the resulting mixture is stirred at 60° C. under an atmosphere of nitrogen for 3 hours. The crude reaction mixture is then filtered through a plug of silica and washed with ethyl acetate, and the filtrate is concentrated to give a brown solid. The crude product is purified by flash chromatography on silica gel to give 2-(4-chlorophenyl)selenazole-5-carbaldehyde (162 mg).

1. customThe crude reaction mixture
2. filtrationis then filtered through a plug of silica
3. washwashed with ethyl acetate
4. concentrationthe filtrate is concentrated
5. customto give a brown solid
6. customThe crude product is purified by flash chromatography on silica gel