1-Methylpiperazine → HCID 66624831, compound

HRID 416667Notes

Reaction equation

HRID 416667 reaction equation
Cl[CH2:2][C:3]1[N:4]2[CH:10]=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[N+:17]([O-:19])=[O:18])[N:8]=[C:5]2[S:6][CH:7]=1.[CH3:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH3:20][N:21]1[CH2:26][CH2:25][N:24]([CH2:2][C:3]2[N:4]3[CH:10]=[C:9]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=4[N+:17]([O-:19])=[O:18])[N:8]=[C:5]3[S:6][CH:7]=2)[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 59679997HCID 59679997, compound

Product 1

HCID 66624831HCID 66624831, compound

Conditions

Temperature
110 °C

Procedure

Displacement: 3-Chloromethyl-6-(2-nitro-phenyl)-imidazo[2,1-b]thiazole (126 mg, 0.300 mmol) in 2 ml of 1-methyl-piperazine was microwave heated at 110° C. for 30 minutes. The reaction mixture was concentrated to dryness, and chased with methanol to obtain crude 3-(4-Methyl-piperazin-1-ylmethyl)-6-(2-nitro-phenyl)-imidazo[2,1-b]thiazole.

Workup

  1. concentrationThe reaction mixture was concentrated to dryness

Sources & evidence

ORD record
ord-f63e9e8a299143b68c0423b9e25ca3a1
Source dataset
uspto-grants-2012_01
Patent number
US08088928B2

Reaction notes

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