Hydrochloric Acid → HCID 178478793, compound

HRID 416690Notes

Reaction equation

HRID 416690 reaction equation
[ClH:1].[P:2]([O-:57])([O-:56])([O:4][C:5](C(C)(C)C)(C(C)(C)C)[C:6]1[CH:11]=[C:10]([N:12](C(OC(C)(C)C)=O)[C:13]([NH2:22])=[N:14]C(OC(C)(C)C)=O)[CH:9]=[C:8]([N:30](C(OC(C)(C)C)=O)[C:31]([NH2:40])=[N:32]C(OC(C)(C)C)=O)[CH:7]=1)=[O:3]>CCOCC>[ClH:1].[ClH:1].[NH:12]([C:10]1[CH:11]=[C:6]([CH:7]=[C:8]([NH:30][C:31]([NH2:40])=[NH:32])[CH:9]=1)[CH2:5][O:4][P:2](=[O:3])([OH:56])[OH:57])[C:13]([NH2:22])=[NH:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86604081HCID 86604081, compound

Product 1

HCID 178478793HCID 178478793, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1 M solution of HCl in ether (35 ml) was added to di-tert-butyl-3,5-Bis(N,N′-bis-Boc-guanidino)benzyl phosphate (0.45 gram, 0.57 mmol) and the resulting mixture was stirred at room temperature for 22-24 hours, during which a white precipitate was formed. The ether was thereafter decanted and the precipitate was washed 3-4 times with dry ether, evaporated and the residue was dried under high vacuum to give 0.13 grams (65%) of the final product.

Workup

  1. customwas formed
  2. customThe ether was thereafter decanted
  3. washthe precipitate was washed 3-4 times with dry ether
  4. customevaporated
  5. customthe residue was dried under high vacuum

Sources & evidence

ORD record
ord-48b80ff4be6245118975d0a74d7e2568
Source dataset
uspto-grants-2012_01
Patent number
US08088941B2

Reaction notes

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