Sodium Hydroxide → HCID 46928681, compound

HRID 416993Notes

Reaction equation

C([O:3][C:4](=[O:43])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:27]=[C:26]([C:28]3[CH:32]=[CH:31][S:30][CH:29]=3)[CH:25]=[C:24]([O:33][CH2:34][CH3:35])[CH:23]=2)[C:10]=1[CH2:36][CH2:37][C:38]([O:40]CC)=[O:39])C.[OH-].[Na+]>>[C:38]([CH2:37][CH2:36][C:10]1[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:27]=[C:26]([C:28]3[CH:32]=[CH:31][S:30][CH:29]=3)[CH:25]=[C:24]([O:33][CH2:34][CH3:35])[CH:23]=2)=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:7][CH2:6][CH2:5][C:4]([OH:43])=[O:3])([OH:40])=[O:39]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 59496825HCID 59496825, compound

Product 1

HCID 46928681HCID 46928681, compoundYield 99%

Procedure

A similar procedure as described in Example 43, step 5 was used, starting from 4-[2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-ethoxy-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy]-butyric acid ethyl ester (150 mg, 0.25 mmol) and 1.0 N aqueous sodium hydroxide (2.5 mL) to afford 4-[2-(2-carboxy-ethyl)-3-[6-(3-ethoxy-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy]-butyric acid (136 mg, 99%) as a light brown waxy solid: ES(+)-HRMS m/e calcd for C31H38O7S (M+H)+ 555.2411, found 555.2410.

Sources & evidence

ORD record: ord-1bf7d6ebfabc40bfa3477e35c7a3580f
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08088936B2

Reaction notes

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