HRID417033

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(C(C)=O)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)OCC

HCID59496822

未命名化合物

PRODUCTS

生成物

结构：CC(=O)c1cc(OCCCCCCc2cccc(OCCCC(=O)O)c2CCC(=O)O)cc(-c2ccc3c(c2)OCO3)c1

HCID46929079

未命名化合物

收率 92%

PROCEDURE

实验过程

A similar procedure as described in Example 43, step 5 was used, starting from 4-[3-[6-(3-acetyl-5-benzo[1,3]-dioxol-5-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (230 mg, 0.36 mmol) and 1.0 N aqueous sodium hydroxide (8 mL) to afford 4-[3-[6-(3-acetyl-5-benzo[1,3]dioxol-5-yl-phenoxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid (192 mg, 92%) as a white solid: ES(+)-HRMS m/e calcd for C34H38O9 (M+Na)+ 613.2408. found 613.2407.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dffa31810a124171bac610481e14f008
来源数据集: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08088936B2
来源说明: uspto-grants-2012_01

反应 SMILES

C([O:3][C:4](=[O:47])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:27]=[C:26]([C:28]3[CH:36]=[CH:35][C:31]4[O:32][CH2:33][O:34][C:30]=4[CH:29]=3)[CH:25]=[C:24]([C:37](=[O:39])[CH3:38])[CH:23]=2)[C:10]=1[CH2:40][CH2:41][C:42]([O:44]CC)=[O:43])C.[OH-].[Na+]>>[C:37]([C:24]1[CH:23]=[C:22]([CH:27]=[C:26]([C:28]2[CH:36]=[CH:35][C:31]3[O:32][CH2:33][O:34][C:30]=3[CH:29]=2)[CH:25]=1)[O:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][C:11]1[C:10]([CH2:40][CH2:41][C:42]([OH:44])=[O:43])=[C:9]([CH:14]=[CH:13][CH:12]=1)[O:8][CH2:7][CH2:6][CH2:5][C:4]([OH:47])=[O:3])(=[O:39])[CH3:38]