HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-[3-[6-(3-Acetyl-5-benzo[1,3]dioxol-5-yl-phenoxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-[3-[6-(3-Acetyl-5-benzo[1,3]-dioxol-5-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester | HCID 59496822 | — |
| Product | 4-[3-[6-(3-Acetyl-5-benzo[1,3]dioxol-5-yl-phenoxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid | HCID 46929079 | 92% |
Reaction Steps
A similar procedure as described in Example 43, step 5 was used, starting from 4-[3-[6-(3-acetyl-5-benzo[1,3]-dioxol-5-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (230 mg, 0.36 mmol) and 1.0 N aqueous sodium hydroxide (8 mL) to afford 4-[3-[6-(3-acetyl-5-benzo[1,3]dioxol-5-yl-phenoxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid (192 mg, 92%) as a white solid: ES(+)-HRMS m/e calcd for C34H38O9 (M+Na)+ 613.2408. found 613.2407.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088936B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-dffa31810a124171bac610481e14f008 |
| Source note | uspto-grants-2012_01 |