HCID 86645714, compound → HCID 86645713, compound

HRID 417034Notes

Reaction equation

HRID 417034 reaction equation
C([O:3][C:4](=[O:48])[CH2:5][CH:6]([O:8][C:9]1[C:14]([CH2:15][CH2:16][CH:17]([C:38](=[O:40])[CH3:39])[CH2:18][CH:19]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[C:28]2[CH:37]=[CH:36][C:31]3[O:32][CH2:33][CH2:34][O:35][C:30]=3[CH:29]=2)[CH3:20])=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:41][CH2:42][C:43]([O:45]CC)=[O:44])[CH3:7])C>[OH-].[Na+]>[C:38]([CH:17]([CH2:18][CH:19]([O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[C:28]1[CH:37]=[CH:36][C:31]2[O:32][CH2:33][CH2:34][O:35][C:30]=2[CH:29]=1)[CH3:20])[CH2:16][CH2:15][C:14]1[C:9]([O:8][CH:6]([CH3:7])[CH2:5][C:4]([OH:48])=[O:3])=[C:10]([CH2:41][CH2:42][C:43]([OH:45])=[O:44])[CH:11]=[CH:12][CH:13]=1)(=[O:40])[CH3:39]

Participants

3

Reactant 1

HCID 86645714HCID 86645714, compound

Product 1

HCID 86645713HCID 86645713, compoundYield 66.1%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A similar procedure as described in Example 43, step 5 was used, starting from 4-[3-[6-(3-acetyl-5-(2,3-dihydro-benzo[1,4]-dioxin-6-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (330 mg, 0.5 mmol) and 1.0 N aqueous sodium hydroxide (10 mL) to afford 4-[3-[6-(3-acetyl-5-(2,3-dihydro-benzo[1,4]dioxin-6-yl-phenoxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid (200 mg, 61%) as a off-white solid: ES(+)-HRMS m/e calcd for C35H40O9 (M+Na)+ 627.2564. found 627.2560.

Sources & evidence

ORD record
ord-5e66ffa629fa4d92bd3da89019b17268
Source dataset
uspto-grants-2012_01
Patent number
US08088936B2

Reaction notes

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