4-[3-[6-(3-Acetyl-5-thiophen-3-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester → 4-[3-[6-(3-Acetyl-5-thiophen-3-yl-phenoxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid

Participants

Reaction Steps

A similar procedure as described in Example 43, step 5 was used, starting from 4-[3-[6-(3-acetyl-5-thiophen-3-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (272 mg, 0.44 mmol) and 1.0 N aqueous sodium hydroxide (10 mL) to afford 4-[3-[6-(3-acetyl-5-thiophen-3-yl-phenoxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid (163 mg, 66%) as a light brown solid: ES(+)-HRMS m/e calcd for C31H36O7S (M+Na)+ 575.2074. found 575.2074.

Provenance & Evidence