1-(2-bromo-1-cyclohexyl-ethyl)-2-(4-chloro-phenyl)-5,6-difluoro-1H-benzoimidazole → 2-(4-Chloro-phenyl)-1-[1-cyclohexyl-2-(pyridin-4-yloxy)-ethyl]-5,6-difluoro-1H-benzoimidazole

HRID 417087Notes

Reaction equation

HRID 417087 reaction equation
Br[CH2:2][CH:3]([N:10]1[C:14]2[CH:15]=[C:16]([F:20])[C:17]([F:19])=[CH:18][C:13]=2[N:12]=[C:11]1[C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=1)[CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1.[OH:28][C:29]1[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=1>>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([C:11]2[N:10]([CH:3]([CH:4]3[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]3)[CH2:2][O:28][C:29]3[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=3)[C:14]3[CH:15]=[C:16]([F:20])[C:17]([F:19])=[CH:18][C:13]=3[N:12]=2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 666193191-(2-bromo-1-cyclohexyl-ethyl)-2-(4-chloro-phenyl)-5,6-difluoro-1H-benzoimidazoleHCID 178418642HCID 178418642, compound

Product 1

HCID 461846832-(4-Chloro-phenyl)-1-[1-cyclohexyl-2-(pyridin-4-yloxy)-ethyl]-5,6-difluoro-1H-benzoimidazole

Procedure

The title compound was prepared in analogy to Example 35 from 1-(2-bromo-1-cyclohexyl-ethyl)-2-(4-chloro-phenyl)-5,6-difluoro-1H-benzoimidazole (Ex. 34, int.) and 4-hydroxypyridine after a reaction time of 3 days at room temperature. White solid (32%). MS (Turbo Spray): m/z=468.2 [M+H].

Sources & evidence

ORD record
ord-c2bed46bb519443cbe2602bd17a0fcc6
Source dataset
uspto-grants-2012_01
Patent number
US08088930B2

Reaction notes

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