HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-bromo-1-cyclohexyl-ethyl)-2-(4-chloro-phenyl)-5,6-difluoro-1H-benzoimidazole → 2-(4-Chloro-phenyl)-1-[1-cyclohexyl-2-(pyridin-4-yloxy)-ethyl]-5,6-difluoro-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-bromo-1-cyclohexyl-ethyl)-2-(4-chloro-phenyl)-5,6-difluoro-1H-benzoimidazole | HCID 66619319 | — |
| Reactant | HCID 178418642 | HCID 178418642 | — |
| Product | 2-(4-Chloro-phenyl)-1-[1-cyclohexyl-2-(pyridin-4-yloxy)-ethyl]-5,6-difluoro-1H-benzoimidazole | HCID 46184683 | — |
Reaction Steps
The title compound was prepared in analogy to Example 35 from 1-(2-bromo-1-cyclohexyl-ethyl)-2-(4-chloro-phenyl)-5,6-difluoro-1H-benzoimidazole (Ex. 34, int.) and 4-hydroxypyridine after a reaction time of 3 days at room temperature. White solid (32%). MS (Turbo Spray): m/z=468.2 [M+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088930B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-c2bed46bb519443cbe2602bd17a0fcc6 |
| Source note | uspto-grants-2012_01 |