HRID417091

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID97268

Di-tert-butyl azodicarboxylate

C10H18N2O4

HCID22087431

Methyl 2,6-difluoro-4-hydroxybenzoate

C8H6F2O3

结构：OCC(C1CCCCC1)n1c(-c2ccc(Cl)cc2)nc2cc(F)c(F)cc21

HCID66619310

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1c(F)cc(OCC(C2CCCCC2)n2c(-c3ccc(Cl)cc3)nc3cc(F)c(F)cc32)cc1F

HCID66619492

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to Example 4, intermediate, from 2-[2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethanol (Ex. 1, int. c) and 2,6-difluoro-4-hydroxy-benzoic acid methyl ester and replacing di-ethyl azodicarboxylate by di-tert-butyl azodicarboxylate. Light yellow oil (85%). MS (Turbo Spray): m/z=561.2 [M+H].

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c0d5bc95af5d462cb0b173e845d17417
来源数据集: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08088930B2
来源说明: uspto-grants-2012_01

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH:13]([CH:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)[CH2:14][OH:15])[C:11]3[CH:22]=[C:23]([F:27])[C:24]([F:26])=[CH:25][C:10]=3[N:9]=2)=[CH:4][CH:3]=1.[CH3:28][O:29][C:30](=[O:40])[C:31]1[C:36]([F:37])=[CH:35][C:34](O)=[CH:33][C:32]=1[F:39].N(C(OC(C)(C)C)=O)=NC(OC(C)(C)C)=O>>[CH3:28][O:29][C:30](=[O:40])[C:31]1[C:32]([F:39])=[CH:33][C:34]([O:15][CH2:14][CH:13]([N:12]2[C:11]3[CH:22]=[C:23]([F:27])[C:24]([F:26])=[CH:25][C:10]=3[N:9]=[C:8]2[C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[CH:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)=[CH:35][C:36]=1[F:37]