反应详情

To a solution of 0.29 g (0.92 mmol) 2-(6-benzyloxy-pyridin-3-yloxy)-2-methyl-propionic acid ethyl ester in 3 mL ethanol 29 mg 10% palladium on charcoal was added. The suspension was hydrogenated at 1.5 bar for 0.75 h. The catalyst was filtered off over Dicalite Speed Plus, washed with ethanol and the filtrate evaporated to dryness to give the desired compound as a light brown solid (94%). MS (Turbo Spray): m/z=226.1 [M+H].

1. filtrationThe catalyst was filtered off over Dicalite Speed Plus
2. washwashed with ethanol
3. customthe filtrate evaporated to dryness