2-(6-Benzyloxy-pyridin-3-yloxy)-2-methyl-propionic acid ethyl ester → 2-(6-Hydroxy-pyridin-3-yloxy)-2-methyl-propionic acid ethyl ester

Participants

Reaction Steps

To a solution of 0.29 g (0.92 mmol) 2-(6-benzyloxy-pyridin-3-yloxy)-2-methyl-propionic acid ethyl ester in 3 mL ethanol 29 mg 10% palladium on charcoal was added. The suspension was hydrogenated at 1.5 bar for 0.75 h. The catalyst was filtered off over Dicalite Speed Plus, washed with ethanol and the filtrate evaporated to dryness to give the desired compound as a light brown solid (94%). MS (Turbo Spray): m/z=226.1 [M+H].

Provenance & Evidence