Glycine tert-butyl ester → HCID 178446421, compound

HRID 417255Notes

Reaction equation

HRID 417255 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[C:10]([Si:14]([CH3:24])([CH3:23])[O:15][CH2:16][C:17]([CH3:22])([CH3:21])[CH2:18][CH:19]=O)([CH3:13])([CH3:12])[CH3:11]>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:19]/[CH2:18][C:17]([CH3:21])([CH3:22])[CH2:16][O:15][Si:14]([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:24])[CH3:23])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 104896714-(Tert-butyl-dimethyl-silanyloxy)-3,3-dimethyl-butyraldehyde

Product 1

HCID 178446421HCID 178446421, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a manner similar to the method described in Example 1, glycine tert-butyl ester (0.52 g, 3.64 mmol) was reacted with 4-(tert-butyl-dimethyl-silanyloxy)-3,3-dimethyl-butyraldehyde (0.84 g, 3.64 mmol) in CH2Cl2 at room temperature for 18 h to give [4-(tert-butyl-dimethyl-silanyloxy)-3,3-dimethyl-but-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (1.25 g, 100%).

Sources & evidence

ORD record
ord-44e06a76580445ff9b83958f8d601c96
Source dataset
uspto-grants-2012_01
Patent number
US08088815B2

Reaction notes

Loading…