反应详情

温度

40 °C

To a solution of rac-4-{[(2′S,3′R,4′S,5′R)-6-chloro-4′-(3-chloro-2-fluoro-phenyl)-2′-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3′-pyrrolidine]-5′-carbonyl]-amino}-3-methoxy-benzoic acid methyl ester (60 mg, 0.096 mmol) in MeOH (4 mL) and THF (6 mL) was added an aqueous solution (2 N) of NaOH (1.2 mL, 2.4 mmol). The reaction mixture was heated to 40° C. and stirred overnight. The crude mixture was diluted with water (5 mL), concentrated in vacuo to remove some organic solvent. The mixture was filtered, and the filtrate was acidified to “pH” 5-6. The suspension was filtered and the solid was collected, washed with water, and dried to give the desired product as a white powder (Yield, 41 mg, 66%). MS (H+), 614.

1. concentrationconcentrated in vacuo
2. customto remove some organic solvent
3. filtrationThe mixture was filtered
4. filtrationThe suspension was filtered
5. customthe solid was collected
6. washwashed with water
7. customdried