反应详情

温度

80 °C

Step A To a solution of 4-fluoro-2-methoxy-1-nitrobenzene (Combi-blocks, 3.4 g, 19.9 mmol) in DMSO (40 mL) was added an aqueous solution (1N) of NaOH (40 mL, 40 mmol). The reaction mixture was heated at 80° C. for 20 h. The mixture was cooled to room temperature, and the “pH” of the solution was adjusted to 5 by aqueous HCl solution. The mixture was extracted with ethyl acetate three times. The combined organic extract was washed with water, brine, dried over MgSO4, and concentrated to give 3-methoxy-4-nitrophenol as a light yellow solid (3.2 g, 95%).

1. temperatureThe mixture was cooled to room temperature
2. extractionThe mixture was extracted with ethyl acetate three times
3. extractionThe combined organic extract
4. washwas washed with water, brine
5. dry with materialdried over MgSO4
6. concentrationconcentrated