反应详情

温度

20 °C

In a 250 mL, 4 necked round bottom flask, equipped with mechanical stirrer, thermometer, reflux condenser and under a flow of nitrogen, D-alaninamide hydrochloride (6.1 g) and methanol (80 mL) are charged and stirred for 15 min at 20° C. Triethylamine (5 g) is added at such a rate that the temperature remains below 30° C. The mixture is stirred for 10 min, whereupon solid 4-(3-fluorobenzyloxy)benzaldehyde (10 g, Example 10 b) is added portion wise in about 30 min. After stirring for 3 hours at 20° C., the mixture is cooled to 5° C. After stirring for 3 hours at this temperature, the solid is filtered and washed with small amount of pre-cooled methanol. The wet solid is dried under vacuum for 12 hours a 25° C., yielding 6.4 g of title compound as white solid, with 46.4% yield; m.p 111.9.

1. customIn a 250 mL, 4 necked round bottom flask, equipped with mechanical stirrer
2. temperaturethermometer, reflux condenser
3. customremains below 30° C
4. additionis added portion wise in about 30 min
5. stirringAfter stirring for 3 hours at 20° C.
6. temperaturethe mixture is cooled to 5° C
7. stirringAfter stirring for 3 hours at this temperature
8. filtrationthe solid is filtered
9. washwashed with small amount of pre-cooled methanol
10. customThe wet solid is dried under vacuum for 12 hours a 25° C.