HCID 14814632, compound → HCID 66651873, compound

HRID 417814Notes

Reaction equation

HRID 417814 reaction equation
[Br-:1].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.[CH:34]1[S:38][CH:37]=[CH:36][C:35]=1[C:39]([CH:41]([CH3:43])[CH3:42])=[O:40]>O1CCCC1>[Br:1][C:41]([C:39](=[O:40])[C:35]1[CH:36]=[CH:37][S:38][CH:34]=1)([CH3:43])[CH3:42]

Participants

4

Reactant 2

HCID 14814632HCID 14814632, compoundHCID 17977687Phenyltrimethylammonium bromide dibromide

Product 1

HCID 66651873HCID 66651873, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2.88 g of phenyltrimethylammonium tribromide was added to a mixed solution comprising 1.54 g of 2-(3-thenoyl)propane and 30 ml of tetrahydrofuran, followed by a reaction at room temperature for 15 hours. After completion of the reaction, the precipitate was separated by filtration and concentrated, and then purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=2/8-4/6) to obtain 0.87 of 2-bromo-2-(3-thenoyl)propane. The NMR spectrum data of this product were as follows.

Workup

  1. customfollowed by a reaction at room temperature for 15 hours
  2. customAfter completion of the reaction
  3. customthe precipitate was separated by filtration
  4. concentrationconcentrated
  5. custompurified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=2/8-4/6)

Sources & evidence

ORD record
ord-7a91fd42ea99491485a07258915fd81a
Source dataset
uspto-grants-2012_01
Patent number
US08093241B2

Reaction notes

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