Water → HCID 23016510, compound

HRID 417815Notes

Reaction equation

HRID 417815 reaction equation
Br[C:2]([C:5](=[O:11])[C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)([CH3:4])[CH3:3].[N-:12]=[N+:13]=[N-:14].[Na+].O>CS(C)=O>[N:12]([C:2]([C:5](=[O:11])[C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)([CH3:4])[CH3:3])=[N+:13]=[N-:14]

Participants

5

Reactant 3

HCID 962WaterHCID 33557Sodium AzideHCID 66651873HCID 66651873, compound

Product 1

HCID 23016510HCID 23016510, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

0.87 of 2-bromo-2-(3-thenoyl)propane was dissolved in 5 ml of dimethyl sulfoxide, then 0.44 g of sodium azide was added thereto and reacted at 70° C. for 1 hour. After completion of the reaction, the reaction mixture was allowed to cool and put into 200 ml of water, and then extracted with ethyl ether. The organic layer was washed with water, then dried over magnesium sulfate, followed by concentration to obtain 0.70 g of 2-azido-2-(3-thenoyl)propane. The NMR spectrum data of this product were as follows.

Workup

  1. customreacted at 70° C. for 1 hour
  2. customAfter completion of the reaction
  3. temperatureto cool
  4. extractionextracted with ethyl ether
  5. washThe organic layer was washed with water
  6. dry with materialdried over magnesium sulfate
  7. concentrationfollowed by concentration

Sources & evidence

ORD record
ord-35794f304f2f4fe296d708651408f0ea
Source dataset
uspto-grants-2012_01
Patent number
US08093241B2

Reaction notes

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