HRID417842

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID137268

2-Ethynyl pyridine

C7H5N

结构：COc1c(C)cnc(Cn2cc(I)c3c(Cl)nc(N)nc32)c1C

HCID44228964

4-Chloro-5-iodo-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine

C15H15ClIN5O

PRODUCTS

生成物

结构：COc1c(C)cnc(Cn2cc(C#Cc3ccccn3)c3c(Cl)nc(N)nc32)c1C

HCID57713834

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by Sonogashira coupling of 4-chloro-5-iodo-7-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine (see, Example 1) with 2-ethynylpyridine according to the General Procedure A. tR: 4.65 min. 1H-NMR (DMSO-d6) δ 8.59 (s, 1H), 8.07 (s, 1H), 7.82 (td, 1H), 7.62 (s, 1H), 7.56 (d, 1H), 7.36 (td, 1H), 6.84 (br. S, 2H), 5.36 (s, 2H), 3.74 (s, 3H), 2.28 (s, 3H), 2.17 (s, 3H).