Ethynylpyridine → 4-Chloro-7-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-5-pyridin-2-ylethynyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine

Participants

Role	Name	HCID	Charge
Reactant	Ethynylpyridine	HCID 137268	—
Reactant	4-Chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine	HCID 44228964	—
Product	4-Chloro-7-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-5-pyridin-2-ylethynyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine	HCID 57713834	—

Reaction Steps

The title compound was prepared by Sonogashira coupling of 4-chloro-5-iodo-7-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine (see, Example 1) with 2-ethynylpyridine according to the General Procedure A. tR: 4.65 min. 1H-NMR (DMSO-d6) δ 8.59 (s, 1H), 8.07 (s, 1H), 7.82 (td, 1H), 7.62 (s, 1H), 7.56 (d, 1H), 7.36 (td, 1H), 6.84 (br. S, 2H), 5.36 (s, 2H), 3.74 (s, 3H), 2.28 (s, 3H), 2.17 (s, 3H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08093229B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-4bed562cc29a48b0a820cde1e55ca277
Source note	uspto-grants-2012_01