反应详情

4-t-Butylphenylhydrazine hydrochloride (24.2 g, 120 mmol) in acetic acid (600 mL) was stirred with ethyl acetoacetate (16.4 mL, 129 mmol) at 100° C. for 22 hours. The solvent was removed by distillation under reduced pressure, and the resulting solid was recrystallized from chloroform (70 ml, 40° C.)-diethyl ether (200 mL, 0° C.), washed with diethyl ether and dried under reduced pressure to give 21.7 g of the desired product (78% yield).

1. customThe solvent was removed by distillation under reduced pressure
2. customthe resulting solid was recrystallized from chloroform (70 ml, 40° C.)-diethyl ether (200 mL, 0° C.)
3. washwashed with diethyl ether
4. customdried under reduced pressure