1-Piperazinecarboxylic acid, ethyl ester → HCID 66651851, compound

HRID 418050Notes

Reaction equation

HRID 418050 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])[CH3:2].[NH:12]([C:26]([O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:27])[C@H:13]([C:23]([OH:25])=O)[CH2:14][CH2:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19].C(Cl)Cl.[CH2:39]1COC[CH2:40]1>>[CH2:1]([O:3][C:4]([N:6]1[CH2:7][CH2:8][N:9]([C:23](=[O:25])[C@@H:13]([NH:12][C:26]([O:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:27])[CH2:14][CH2:15][C:16]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:22])[CH:10]([CH2:39][CH3:40])[CH2:11]1)=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 1074725-tert-Butyl N-((phenylmethoxy)carbonyl)-L-glutamateHCID 21919333Tetrahydrofurane dichloromethane

Product 1

HCID 66651851HCID 66651851, compound

Procedure

This compound was prepared using a method analogous to that of Example 22. step 22.1, intermediate 23.1 replacing 1-(ethoxycarbonyl)piperazine, and Z-(L)-Glu(OtBu)-OH replacing Boc-β-cyano-(L)-Ala-OH, but in DCM/THF (10 ml, 1:1).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-df8cf24eda5040ee815c0e66ea6b510b
Source dataset
uspto-grants-2012_01
Patent number
US08093250B2

Reaction notes

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