HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Piperazinecarboxylic acid, ethyl ester → 4-((s)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyryl)-3-ethyl-piperazine-1-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Piperazinecarboxylic acid, ethyl ester | HCID 8431 | — |
| Reactant | 5-tert-Butyl N-((phenylmethoxy)carbonyl)-L-glutamate | HCID 107472 | — |
| Reactant | Tetrahydrofurane dichloromethane | HCID 21919333 | — |
| Product | 4-((s)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyryl)-3-ethyl-piperazine-1-carboxylic acid ethyl ester | HCID 66651851 | — |
Reaction Steps
This compound was prepared using a method analogous to that of Example 22. step 22.1, intermediate 23.1 replacing 1-(ethoxycarbonyl)piperazine, and Z-(L)-Glu(OtBu)-OH replacing Boc-β-cyano-(L)-Ala-OH, but in DCM/THF (10 ml, 1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093250B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-df8cf24eda5040ee815c0e66ea6b510b |
| Source note | uspto-grants-2012_01 |