反应详情

MCPBA (28.1 g) was added to a solution of 4-chloro-3-fluoro-pyridine (10.0 g) in DCM (150 ml) and the reaction mixture stirred for 60 h at RT. The reaction mixture was quenched with 10% aq. Na2S2O3 and the basicity of the aq. phase adjusted with aq. sat. Na2CO3 to pH 9. The aq. phase was extracted with EA (6×), and the combined org. phase was dried over MgSO4 and evaporated to dryness. The desired compound (8.4 g) was used in the next step without further purification.

1. customThe reaction mixture was quenched with 10% aq. Na2S2O3
2. extractionThe aq. phase was extracted with EA (6×)
3. dry with materialphase was dried over MgSO4
4. customevaporated to dryness
5. customThe desired compound (8.4 g) was used in the next step without further purification