反应详情

温度

60 °C

To a solution of 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-iodo-5-methanesulfonyl-phenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester (0.9 g, 1.31 mmol) in hot ethanol (40 mL) was added aqueous 1.0 N sodium hydroxide (10 mL). The resulting solution was heated to 60° C. and stirred for 4 h. Then, the reaction mixture was cooled down and diluted with EtOAc, washed with 10% HCl and brine. The combined ethyl acetate extracts were dried over anhydrous sodium sulfate, concentrated under reduced pressure to afford 805 mg (97%) of title compound as a light yellow oil. HR-ES(+) m/e calcd for C26H33O8SI (M+H)+ 633.1014, found 633.1008.

1. temperatureThen, the reaction mixture was cooled down
2. washwashed with 10% HCl and brine
3. dry with materialThe combined ethyl acetate extracts were dried over anhydrous sodium sulfate
4. concentrationconcentrated under reduced pressure