4-(2-(2-Ethoxycarbonyl-ethyl)-3-{6-[3-methanesulfonyl-5-(2-methylsulfanyl-pyrimidin-4-yl)-phenoxy]-hexyl}-phenoxy)-butyric acid ethyl ester → 4-{2-(2-Ethoxycarbonyl-ethyl)-3-[6-(3-methanesulfonyl-5-pyrimidin-4-yl-phenoxy)-hexyl]-phenoxy}-butyric Acid Ethyl Ester

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Reaction Steps

To a solution of 4-(2-(2-ethoxycarbonyl-ethyl)-3-{6-[3-methanesulfonyl-5-(2-methylsulfanyl-pyrimidin-4-yl)-phenoxy]-hexyl}-phenoxy)-butyric acid ethyl ester (292 mg, 0.423 mmol) in MeOH (15 ml) and THF (15 mL), Raney Ni (2 mL) was added, and stirred at r.t. for 3 h. The reaction was filtered, the residue was washed with MeOH, concentration gave an oil which was used in the next step without further purification. (164 mg).

Provenance & Evidence