反应详情

To a solution of 4-(2-(2-ethoxycarbonyl-ethyl)-3-{6-[3-methanesulfonyl-5-(2-methylsulfanyl-pyrimidin-4-yl)-phenoxy]-hexyl}-phenoxy)-butyric acid ethyl ester (292 mg, 0.423 mmol) in MeOH (15 ml) and THF (15 mL), Raney Ni (2 mL) was added, and stirred at r.t. for 3 h. The reaction was filtered, the residue was washed with MeOH, concentration gave an oil which was used in the next step without further purification. (164 mg).

1. filtrationThe reaction was filtered
2. washthe residue was washed with MeOH, concentration
3. customgave an oil which
4. customwas used in the next step without further purification