Sodium Hydroxide → HCID 57863014, compound

HRID 418087Notes

Reaction equation

C([O:3][C:4](=[O:49])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:23]=[C:24]([C:32]3[CH:37]=[CH:36][C:35]([S:38]([CH3:41])(=[O:40])=[O:39])=[CH:34][CH:33]=3)[CH:25]=[C:26]([S:28]([CH3:31])(=[O:30])=[O:29])[CH:27]=2)[C:10]=1[CH2:42][CH2:43][C:44]([O:46]CC)=[O:45])C.[OH-].[Na+]>>[CH3:31][S:28]([C:26]1[CH:27]=[C:22]([O:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][C:11]2[C:10]([CH2:42][CH2:43][C:44]([OH:46])=[O:45])=[C:9]([CH:14]=[CH:13][CH:12]=2)[O:8][CH2:7][CH2:6][CH2:5][C:4]([OH:49])=[O:3])[CH:23]=[C:24]([C:32]2[CH:33]=[CH:34][C:35]([S:38]([CH3:41])(=[O:40])=[O:39])=[CH:36][CH:37]=2)[CH:25]=1)(=[O:30])=[O:29]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 57863029HCID 57863029, compound

Product 1

HCID 57863014HCID 57863014, compoundYield 58.9%

Procedure

A similar procedure as described in Example 40, step 8 was used, starting from 4-[3-[6-(5,4′-bis-methanesulfonyl-biphenyl-3-yloxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (67 mg, 0.09 mmol) and 1.0 N aqueous sodium hydroxide (0.9 mL) to afford 4-[3-[6-(5,4′-bis-methanesulfonyl-biphenyl-3-yloxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid (35 mg, 57%) as an amorphous white solid: ES(+)-HRMS m/e calcd for C33H40O10S2 (M+Na)+ 683.1955, found 683.1954.

Sources & evidence

ORD record: ord-9326066992b44f609280b6c7f887163b
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08093253B2

Reaction notes

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