反应详情

3,5-Dibromophenol (10.0 g), 4-methoxybenzyl bromide (8.8 g) and potassium carbonate (27.3 g) were combined in acetone (300 mL) and refluxed for 3 h. Then the insoluble material was removed by filtration, the filtrate was concentrated under reduced pressure and the resulting crude oil was purified on a silica gel column using ethyl acetate and hexanes to give light yellow oil which was then crystallized from hexanes to give the title compound (12.1 g, 82% yield). HRMS calcd for C14H12O2Br2 M+ 369.9203, observed 369.9198.

1. temperaturerefluxed for 3 h
2. customThen the insoluble material was removed by filtration
3. concentrationthe filtrate was concentrated under reduced pressure
4. customthe resulting crude oil was purified on a silica gel column
5. customto give light yellow oil which
6. customwas then crystallized from hexanes