HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 57863025, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | (4-Fluoro-3-hydroxyphenyl)boronic acid | HCID 44717470 | — |
| Reactant | HCID 57863128 | HCID 57863128 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | HCID 57863025 | HCID 57863025 | 99.2% |
Reaction Steps
A similar procedure as described in Example 41, step 1 was used, starting from 4-[3-[6-(3-bromo-5-ethanesulfonyl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (213 mg, 0.32 mmol), 4-fluoro-3-hydroxy-phenylboronic acid (101 mg, 0.64 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (37 mg, 0.05 mmol), and cesium carbonate (317 mg, 0.97 mmol) to afford 4-[3-[6-(5-ethanesulfonyl-4′-fluoro-3′-hydroxy-biphenyl-3-yloxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (218 mg, 99%) as a colorless viscous oil: ES(+)-HRMS m/e calcd for C37H47FO9S (M+Na)+ 709.2817, found 709.2817.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093253B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-8886261d828f445ca757e8e0095fd66b |
| Source note | uspto-grants-2012_01 |