Sodium Hydroxide → HCID 57863050, compound

HRID 418113Notes

Reaction equation

C([O:3][C:4](=[O:45])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:27]=[C:26]([C:28]3[CH:32]=[CH:31][S:30][CH:29]=3)[CH:25]=[C:24]([S:33]([CH2:36][CH3:37])(=[O:35])=[O:34])[CH:23]=2)[C:10]=1[CH2:38][CH2:39][C:40]([O:42]CC)=[O:41])C.[OH-].[Na+]>>[C:40]([CH2:39][CH2:38][C:10]1[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:27]=[C:26]([C:28]3[CH:32]=[CH:31][S:30][CH:29]=3)[CH:25]=[C:24]([S:33]([CH2:36][CH3:37])(=[O:34])=[O:35])[CH:23]=2)=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:7][CH2:6][CH2:5][C:4]([OH:45])=[O:3])([OH:42])=[O:41]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 57863120HCID 57863120, compound

Product 1

HCID 57863050HCID 57863050, compoundYield 52%

Procedure

A similar procedure as described in Example 40, step 8 was used, starting from 4-[3-[6-(3-ethanesulfonyl-5-thiophen-3-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (111 mg, 0.17 mmol) and 1.0 N aqueous sodium hydroxide (1.7 mL) to afford 4-[2-(2-carboxy-ethyl)-3-[6-(3-ethanesulfonyl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy]-butyric acid (53 mg, 52%) as an amorphous white solid: ES(+)-HRMS m/e calcd for C31H38O8S2 (M+Na)+ 625.1900, found 625.1904.

Sources & evidence

ORD record: ord-ae3c0acbc06444caac4ec4c2f3f90194
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08093253B2

Reaction notes

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