Sodium Hydroxide → HCID 57863023, compound

HRID 418124Notes

Reaction equation

C([O:3][C:4](=[O:49])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:23]=[C:24]([C:34]3[CH:39]=[CH:38][C:37]([F:40])=[C:36]([F:41])[CH:35]=3)[CH:25]=[C:26]([S:28]([CH2:31][CH2:32][CH3:33])(=[O:30])=[O:29])[CH:27]=2)[C:10]=1[CH2:42][CH2:43][C:44]([O:46]CC)=[O:45])C.[OH-].[Na+]>>[C:44]([CH2:43][CH2:42][C:10]1[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:23]=[C:24]([C:34]3[CH:39]=[CH:38][C:37]([F:40])=[C:36]([F:41])[CH:35]=3)[CH:25]=[C:26]([S:28]([CH2:31][CH2:32][CH3:33])(=[O:29])=[O:30])[CH:27]=2)=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:7][CH2:6][CH2:5][C:4]([OH:49])=[O:3])([OH:46])=[O:45]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 57863110HCID 57863110, compound

Product 1

HCID 57863023HCID 57863023, compoundYield 46%

Procedure

A similar procedure as described in Example 40, step 8 was used, starting from 4-[2-(2-ethoxycarbonyl-ethyl)-3-[6-(5-(propane-1-sulfonyl)-3′,4′-difluoro-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid ethyl ester (130 mg, 0.19 mmol) and 1.0 N aqueous sodium hydroxide (1.9 mL) to afford 4-[2-(2-carboxy-ethyl)-3-[6-(5-(propane-1-sulfonyl)-3′,4′-difluoro-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid (55 mg, 46%) as an amorphous white solid: ES(+)-HRMS m/e calcd for C34H40F2O8S (M+Na)+ 669.2304, found 669.2299.

Sources & evidence

ORD record: ord-601d624cd7f94510bd164fdd7b76c3f5
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08093253B2

Reaction notes

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