Sodium Hydroxide → HCID 57863023, compound

Participants

Reaction Steps

A similar procedure as described in Example 40, step 8 was used, starting from 4-[2-(2-ethoxycarbonyl-ethyl)-3-[6-(5-(propane-1-sulfonyl)-3′,4′-difluoro-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid ethyl ester (130 mg, 0.19 mmol) and 1.0 N aqueous sodium hydroxide (1.9 mL) to afford 4-[2-(2-carboxy-ethyl)-3-[6-(5-(propane-1-sulfonyl)-3′,4′-difluoro-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid (55 mg, 46%) as an amorphous white solid: ES(+)-HRMS m/e calcd for C34H40F2O8S (M+Na)+ 669.2304, found 669.2299.

Provenance & Evidence