反应详情

温度

50 °C

1-[4-((1R,2S,3R)-1,2,3,4-Tetrahydroxy-butyl)-1H-imidazol-2-yl]-ethanone (194 mg, 0.84 mmol) was suspended in ethanol (4 ml) and water (1 ml). 3-chlorobenzoic acid hydrazide (170 mg, 1.0 mmol, 1.2 eq.) and hydrochloric acid (one drop, 12 N) were added, and the suspension was stirred at 50° C. for 48 hours. LCMS analysis indicated the formation of the product and the absence of starting material. The reaction mixture was cooled to room temperature, and partially concentrated in vacuo. The resulting white precipitate was collected and washed with ethanol to yield the product, as a ˜3:1 E:Z mixture, as a white solid: 108 mg (33%).

1. temperatureThe reaction mixture was cooled to room temperature
2. concentrationpartially concentrated in vacuo
3. customThe resulting white precipitate was collected
4. washwashed with ethanol
5. customto yield the product