HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carboxylic acid [4-di-methylamino-4-(3-fluorophenyl)cyclohexyl]amide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carboxylic acid [4-dimethylamino-4-(3-fluorophenyl)cyclohexyl]amide | HCID 11691670 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carboxylic acid [4-di-methylamino-4-(3-fluorophenyl)cyclohexyl]amide hydrochloride | HCID 66651083 | — |
Reaction Steps
As described for Example 122, 448 mg of the polar diastereoisomer of 3-(2,6-dichlorophenyl)-5-methylisoxazole-4-carboxylic-acid [4-dimethylamino-4-(3-fluorophenyl)cyclohexyl]amide were obtained, which, dissolved in 15 ml 2-butanone, 15 ml ethyl acetate and 2 ml methanol, were converted into the corresponding hydrochloride by adding 16.5 μl water, 116 μl chlorotrimethylsilane and 25 ml diusopropylether (364 mg of white solid, Mp. 246-248° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093272B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-ca3e899430664d5c897c6481e22a9c1a |
| Source note | uspto-grants-2012_01 |