反应详情

As described for Example 122, 448 mg of the polar diastereoisomer of 3-(2,6-dichlorophenyl)-5-methylisoxazole-4-carboxylic-acid [4-dimethylamino-4-(3-fluorophenyl)cyclohexyl]amide were obtained, which, dissolved in 15 ml 2-butanone, 15 ml ethyl acetate and 2 ml methanol, were converted into the corresponding hydrochloride by adding 16.5 μl water, 116 μl chlorotrimethylsilane and 25 ml diusopropylether (364 mg of white solid, Mp. 246-248° C.).

1. customwere obtained