Hydrochloric Acid → HCID 86639090, compound

HRID 418342Notes

Reaction equation

HRID 418342 reaction equation
[ClH:1].[CH3:2][N:3]([CH2:5][C:6]1[S:10][C:9]([NH:11]C(=O)C)=[N:8][CH:7]=1)[CH3:4].Cl>CCO.O1CCOCC1>[ClH:1].[ClH:1].[CH3:2][N:3]([CH2:5][C:6]1[S:10][C:9]([NH2:11])=[N:8][CH:7]=1)[CH3:4]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86639091HCID 86639091, compound

Product 1

HCID 86639090HCID 86639090, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
50 °C

Procedure

Dissolved N-(5-dimethylaminomethyl-thiazol-2-yl)-acetamide hydrochloride (300 mg, 1.27 mmol) in 5 mL of EtOH. Added 2 mL of 4 M HCl in dioxane and heated at 50° C. for 16 h. LC-MS analysis indicated complete acetyl removal. Concentrated to give 5-dimethylaminomethyl-thiazol-2-ylamine dihydrochloride.

Workup

  1. customacetyl removal
  2. concentrationConcentrated

Sources & evidence

ORD record
ord-e9e688bb725b44579862f0cb2b1d0d55
Source dataset
uspto-grants-2012_01
Patent number
US08093266B2

Reaction notes

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